The Leader in “Nano Hemp Science”

Currently, NanoBiologics has developed a Proprietary IP Technology nanosizing technology that allows for multiple applications within the hemp industry.

Our technology reduces the molecular conglomeration of hemp molecules to such an extremely small size that we are able to “encapsulate” the hemp molecules with a jacket of water molecules that render the hemp 100% biologically available at the cellular level. In comparison, hemp-infused products using oils or isolates where bio-availability ranges from 35%-55% (smoking or vaporizing) to a low of 8%-14% for infused edibles and beverages. Even medicines developed with the hemp extracted oils such as hemp and THC although extremely concentrated and the potency can be very high, the amount the body can actually absorb into the cellular matrix is less than 50% in the best cases. NanoBiologics solves all these problems and more.

NanoBiologics solutions can be easily incorporated into any recipe that uses water or milk or any water compatible liquid in the recipe.

In hemp delivery systems such as capsules, patches and sub-lingual deliveries nano molecules can be dosed extremely accurately down to the 1/10th of a milligram.

Fundamental Concepts of Nanotechnology

Nanotechnology is based on molecular size. One nanometer is one billionth of a meter. Itʼs hard to imagine just how small that is, let’s take a look:

  • There are 25,400,000 nanometers in an inch.
  • A sheet of newspaper is about 100,000 nanometers thick.
  • On a comparative scale, if a marble were a nanometer, then one meter would be the size of the Earth.

Nanoscience involves the ability to see and to control individual molecules.

Everything on Earth is made up of molecules, the food we eat, the medicines we take, the clothes we wear, the buildings and houses we live in, and our own bodies.

Research Library

Taking Hemp to the Molecular Level

 

Greater than 80 have been identified as phytohemp.More than a dozen have been identified as major terpenes.|

Hemp derivatives inclusive of terpenes produce an “entourage effect.” wherein they work together to enhance bioavailability. Their relative concentrations depend on a number of factors including hemp strain, plant genetics, soil climate conditions, cultivation techniques and most critically, the extraction technology for producing hemp concentrates.

Limitations of Current Methods of Use

 

Current Delivery Methods (Titration) of Hemp Products Include:

Inhalation — Smoking or vaporization // Oral — Edibles, extract oils, tinctures, soft gel caps, drinks, tablets, lozenges and gum. //  Intra-oral — Sprays, tinctures, extracts, and emulsion compositions and hemp-containing chewing gums

Each of the Delivery Methods above have unique challenges.

Smoking and vaporization cannot be dosed accurately.

Cellular absorption following smoking and vaporization was reported to be between 2% – 56% bio-availablity,

Bioavailability varies according to depth of inhalation, duration and breath retention.

About 30% of the THC present in a hemp cigarette is destroyed at combustion.

Vaporization is preferred to smoking however retains the same dosing challenges

Intra-Oral delivery methods of hemp:

Sprays (similar to Sativex)

Tinctures (a drop under the tongue)

Trokies (in the buckle of your teeth)

These delivery systems are further enhanced through nano technology.

Oral delivery methods through infused edibles, beverages and ingested medicine.

Oral absorption of THC is slow and unpredictable, with peak blood concentrations occurring 1-5 hours after ingestion.

Psychotropic effects after oral use have been shown to set in after 30-90 minutes, peak between 2 to 4 hours, and decline to low levels after 6 hours.

The oral absorption of THC and Hemp are typically reported as 6% bioavailability (4%-12%) to the systemic circulation.

Initial degradation of THC is caused by digestive acids in the stomach and intestine. Extensive first-pass liver metabolism further reduces oral bioavailability of THC before it reaches the targets of delivery.

The hydroxylation of ingested THC in the liver to 11-hydroxy-THC creates significantly higher levels of this metabolite compared with inhalation that produces stronger psychotropic effects and greater tendency for adverse effects without warning.

NanoBiologics solutions can be easily incorporated into any recipe that uses water or milk or any water compatible liquid in the recipe.

In hemp delivery systems such as capsules, patches and sub-lingual deliveries nano molecules can be dosed extremely accurately down to the 1/10th of a milligram.

Cannabinoids, like all oils, are poorly soluble in water. Through our technology, cannabinoid molecules become water compatible, thus rendering the highest bioavailability possible.

Enhanced Oral Bioavailablility

NanoSphere encapsulated nutrients are transformed into stable viscoelastic nanoparticles. A major advancement in delivery technology

  • Nanosized nutrients are proven effective as carriers for sublingual, buccal, intranasal, oral and transdermal delivery. Their fluidity, adhesive and viscoelastic properties effectively transport the nutrients across cell mucosal membranes into the bloodstream, past the blood-brain barrier, binding the receptors and signal transduction.
  • As a delivery platform, nanosized nutrients promote effective cellular loading precision-metered dosages through intra-nasal, intra-oral, perusal and transdermal routes of administration

Nanosized ingredients may increase the bioavailability of
nutrients 2-fold to 8-fold.

Nanoparticles can increase water compatibility and stability of phytochemicals, enhance their absorption, protect them from premature degradation in the body, and prolong their circulation time.