Taking Cannabis To The Molecular Level

Cannabinoids are NOT User Friendly

Within the cannabis plant there are at least 480 distinct compounds. Among those at least 111 have been identified as phytocannabinoids and another 111 have been identified as terpenes. The principal cannabinoids appear to be delta-9-tetrahydrocannabinol (69-THC) cannabinol (CBN), and cannabidiol (CBD). Working together they produce "Entourage Effects." Their relative concentrations depends on a number of factors such as the cannabis strain plant genetics, the soil climate conditions, the cultivation techniques and most important the extraction technology for producing cannabis extracts.

Cannabinoids are nearly insoluble in water. Their poor solubility and low dissolution rate in the aqueous gastrointestinal fluids and significant first-pass liver metabolism result in low and unpredictable oral cannabinoid bioavailability Consequentially, cannabinoids require high doses to reach therapeutic plasma concentrations, especially when ingested.

Owing to their lipophilicity, cannabinoids accumulate in the lipid part of cell membranes and occupy binding sites localized on hydrophobic portions of integral membrane proteins. It is thought that various adverse effects associated with chronic use of cannabis, including increased tolerance over time, result from the interaction of cannabinoids with cell membranes. Furthermore, cannabinoids exhibit a slow clearance from the body.

Carbon atoms abstract

The Delivery Solution

NanoSphere encapsulated cannabinoids are manufactured as stable viscoelastic nanoparticles and a major advancement in delivery technology.

  • Nanosized Cannabinoids, are proven effective as carriers for sublingual, buccal, intranasal, oral and transdermal delivery. Their fluidity, adhesive and viscoelastic properties effectively transport cannabinoids across cell mucosa I membranes into the blood stream, past the blood brain barrier, binding to receptors and signal transduction.
  • As a delivery platform, Nanosized Cannabinoids effective cannabinoid loading and allows administering precision-metered dosages through intra-nasal, intra-oral, perusal and transdermal routes of administration.
  • Nanosized Cannabinoids can enter the bloodstream within 15 minutes and achieve peak blood concentrations within 60 minutes.
  • Nanosized Cannabinoids can increase the bioavailability bioactivity of cannabinoids 2-fold to 8-fold compared to bioavailability without encapsulation.
  • Nanosized Cannabinoids can decrease the dose of cannabinoids 2-fold to 8-fold less than an amount of cannabinoids needed to produce the same effect compared to non-encapsulated cannabinoids.
  • Lipid based Nanosized Cannabinoids are highly-stable, biocompatible, biodegradable and easily produced by versatile and scalable and replicable unified sequential assembly process.

Nanoparticles can increase solubility and stability of phytochemicals, enhance their absorption, protect them from premature degradation in the body, and prolong their circulation time.


NanoBiologics Research Corporation
24910 Washington Ave.

Murrieta, CA 92562
(555) 555.5555